应用SPECT观察激素对股骨头血流动力学影响的实验研究

Experimental Study of Effect on Blood Dynamics of Steroid Femoral Head Using SPECT

目的探讨应用激素后股骨头血流动力学及与组织病理学之间的关系。方法选择４２只大耳白兔，随机分为对照组、实验组；实验组肌注甲基强的松龙制备股骨头缺血坏死的动物模型，用放射性核素显像监测股骨头血流动力学改变，并与组织病理相对照。结果应用激素后股骨头血流量２周下降为正常的６５％，４～６周最低，仅为正常的５９％，经计算机ＰＯＭＳ软件处理，Ｆ检验，与对照组有显著差异（Ｐ＜０．０１）。结论由于激素的缩血管作用，家兔股骨头动脉痉挛收缩，组织缺血，导致骨缺血坏死。

Objective To investigate correlation between blood flow changes and physiology.Methods 42 rabbits were divided into two groups randomly,a control group and an experimental group.The experimental group was injected with methypredrisolone for establishing rabbit models of ischemic necrosis of femoral head.Then, SPECT was used to detect blood flow changes in comparison with phyisopathology.Results Two weeks after injection of steroid, blood flow of femoral head decreased 65% of normal, the lowerest blood flow was only 59% of normalin 4～6 weeks later. This results showed significant difference between the two groups by using POMS package analysis and F test (P<0.01).Conclusion The vasoconstrictive action of steroid leads to femoral head artery spasmodic contraction,tissue ischemia and osteonecrosis.