摘要
目的探讨应用激素后股骨头血流动力学及与组织病理学之间的关系。方法选择42只大耳白兔,随机分为对照组、实验组;实验组肌注甲基强的松龙制备股骨头缺血坏死的动物模型,用放射性核素显像监测股骨头血流动力学改变,并与组织病理相对照。结果应用激素后股骨头血流量2周下降为正常的65%,4~6周最低,仅为正常的59%,经计算机POMS软件处理,F检验,与对照组有显著差异(P<0.01)。结论由于激素的缩血管作用,家兔股骨头动脉痉挛收缩,组织缺血,导致骨缺血坏死。
Objective To investigate correlation between blood flow changes and physiology.Methods 42 rabbits were divided into two groups randomly,a control group and an experimental group.The experimental group was injected with methypredrisolone for establishing rabbit models of ischemic necrosis of femoral head.Then, SPECT was used to detect blood flow changes in comparison with phyisopathology.Results Two weeks after injection of steroid, blood flow of femoral head decreased 65% of normal, the lowerest blood flow was only 59% of normalin 4~6 weeks later. This results showed significant difference between the two groups by using POMS package analysis and F test (P<0.01).Conclusion The vasoconstrictive action of steroid leads to femoral head artery spasmodic contraction,tissue ischemia and osteonecrosis.
出处
《中华物理医学杂志》
CAS
CSCD
1998年第1期42-45,共4页
Chinese Journal of Physical Medicine and Rehabilitation
基金
河北省科学技术委员会资助
关键词
股骨头坏死
SPECT
血流动力学
femur head necrosis/physiopathol
femur head neorosis/radionuclide
prednisolone/adv eff
hemodynamics