泌乳素垂体腺瘤的临床特点与诊断治疗

Clinical characteristics, diagnosis and treatment of prolactin pituitary adenoma

目的探讨泌乳素（PRL）垂体腺瘤的临床特点与诊治。方法回顾性分析手术治疗的45例侵袭性PRL垂体腺瘤和67例非侵袭性PRL垂体腺瘤的临床表现、内分泌学表现和影像学资料及治疗效果。结果大垂体腺瘤侵袭性发生率（50．8％）明显高于小腺瘤和微腺瘤侵袭性发生率（21．1％），差异有统计学意义（P〈0．01）；侵袭性垂体腺瘤瘤卒中的发生率（24．4％）明显高于非侵袭性垂体腺瘤瘤卒中的发生率（7．5％），差异有统计学意义（P〈0．05）；侵袭性垂体腺瘤中复发性垂体瘤的发生率（40．0％）明显高于非侵袭性垂体腺瘤瘤复发性垂体瘤的发生率（7．5％），差异有统计学意义（P〈0．01）；侵袭性垂体腺瘤与非侵袭性垂体腺瘤全切除率分别为42．2％和69．6％．差异有统计学意义（P〈0．01）。结论侵袭性垂体腺瘤的诊断治疗复杂，术后需综合治疗。

Objective To prove the clinical characteristics, diagnosis and treatment of prolactin pituitary adenoma. Methods The clinical presentations, imaging studies, endocrine and surgical outcomes in 45 patients with invasive prolaetin pituitary adenomas and 67 patients with nonin - vasive prolactin pituitary adenomas were analyzed retrospectively. Results Invasive pituitary adenomas were more common in patients with macroadenomas than those with micro- adenomas（ P 〈0. 01 ）. The occurrence of pituitary apoplexy was higher in invasion pituitary adenomas patients than those noninvasion （ P 〈 0.05 ）. The rate of total tumor resection was lower and the rate of post operative recurrence was higher in patients with invasive tumors than those with noninvasive tumors （ P 〈 0. 01 ）. Conclusions The diagnosis and treatment of invasion prolactin pituitary adenoma are complicated. The postoperation treatment is often necessary in invasive pituitary adenoma patients.