甲泼尼龙治疗儿童中、重型支气管哮喘50例疗效观察

Efficacy analysis of methylprednisolone in the treatment of children with moderate/severe bronchial asthma

目的观察甲泼尼龙治疗儿童中、重型支气管哮喘的疗效。方法选择50例中、重型支气管哮喘患儿，随机分成治疗组和对照组，其中治疗组26例，对照组24例。两组均给予布地奈德＋硫酸沙丁胺醇＋盐水雾化吸入，同时根据病情给予吸氧抗感染、镇静等综合治疗。治疗组给予上述药物治疗的同时，每6小时给予甲泼尼龙1～2mg／kg，加入50—100ml的5％葡萄糖注射液中静脉滴注，用药3d，观察两组治疗效果。结果治疗组临床总有效率为96．2％，大于对照组的66．7％（P〈0．01）。结论甲泼尼龙联合雾化治疗小儿中、重型支气管哮喘疗效较好。

Objective To observe the effects of methylprdalnisolone in the treatment of children with moderate/severe bronchial asthma. Methods Fifty bronchial asthma patients were randomly divided into treatment group and control group. Twenty - six cases in the treatment group and 24 cases in the control group. All the subjects were given aerosol inhalation with budesonide, salbutamol and sodium chloride, meanwhile, oxygen inhaling, anti -infection, sedation and other combined therapy were given in both groups. At the same time, methy lprednisolone were given endovenous every 6 hours with the dose of 1 -2 mg/kg each time,dissolving in 5% glucose in the treatment group. The effects was compared after three days. Results The clinical effect rates in the treatment group and control group were 96.2% and 66.7% （ P 〈 0.01 ）. Conclusions Combined with budesonide, salbutamol and ambroxol aerosol inhalation is more effective in the treatment of children with moolerate/severe bronchial asthma.