三联疗法治疗幽门螺杆菌感染的疗效分析

Curative effects of triple therapy in children with helicobacter pylori infection

目的研究克拉霉素、阿莫西林、奥美拉唑三联疗法对幽门螺杆菌（Hp）感染的根除率及远期疗效。方法选择经胃镜检查、组织活检确诊为Hp感染患儿108例。随机分为A、B、C三组。A组治疗方案：阿莫西林50mg／（kg·d）、甲硝唑15～20mg／（kg·d）、奥美拉唑0．8mg／（kg·d），疗程2周。B组治疗方案：阿莫西林50mg／（kg·d）、枸橼酸钠7～8mg／（kg·d）、甲硝唑15～20mg／（kg·d），疗程2周。C组治疗方案：阿莫西林50mg/（kg·d）、卡拉霉素15mg／（kg·d）、奥关拉唑0．8mg／（kg·d）、疗程2周。结果A组Hp根除率72．5％，B组Hp根除率75．8％，C组Hp根除率94．3％。C组与A、B组比较差异有统计学意义（P〈0．05）。结论以克拉霉素、阿莫西林、奥关拉唑三联治疗儿童Hp感染，具有疗程短、疗效高、耐药少、依从性好、Hp根除率高等优点。

Objective To evaluate the eradication rate and long - term therapeutic effect of a triple therapy consisted of clarithromycim （CLA）. Methods A total of 108 children with Hp infection were divided into three groups： Group A was treated with amoxicillin 50 mg/（kg·d） ＋ metronidzole 15 -20 mg/（kg·d） ＋ omeperazole 0.8 mg/（ kg·d） for 2 weeks. Group B was treated with amoxieiuin 50 mg/（kg· d） ＋ bismuth citrate 7-8 mg/（ kg·d） ＋ metronidzole 15 -20 mg/（ kg·d） for 2 weeks. Group C was treated with clarithromycin 15 rag/（ kg·d） ＋ amoxiciuin 50 mg/（kg·d） ＋ omeperazole 0.8 mg/（kg·d） for 2 weeks. Results The rates of eradicate of Hp：group A 72.5% ,group B 75.8% , group C 94.3%. The differences between group C and group A, B were very significant. Conclusions Triple therapy is more effective, less duration, well tolerated, less resistant, with higher rate of eradication.