创伤性休克及复苏后肠粘膜免疫功能的改变

Experimental study of changes of intestinal immunity following traumatic shock and resuscitation

目的:研究大鼠休克及复苏后胆汁IgA和血内毒素含量的变化及两者的相关性。方法:大鼠剖腹术后经股动脉放血及自体血回输的方法复制创伤性休克、复苏模型。结果:大鼠休克及复苏后胆汁IgA显著低于休克前,以复苏后24小时最低,并显著低于休克末(P<0.05)。休克及复苏后大鼠门、体循环血内毒素含量均明显高于休克前,以复苏后24小时最高,并显著高于休克末(P<0.05)。胆汁中IgA与血内毒素变化呈显著负相关。结论:创伤性休克及复苏后肠特异性免疫功能显著降低及血内毒素含量增加。

Objective: We investigated experimentally the changes of intestinal immunity following shock and resuscitation after trauma. Method:The experimental model was made in rats, which underwent laparotomy, then bleeding and reinfusing through the right fetmoral artery. Result: The concentration of IgA following shock and resuscitation were significantly higher than that before shock.. The concentration of IgA 24 h following resuscitation was the lowest, and was significantly lower than that at the end of shock.. The endotoxin in portal vein following shock and resuscitation were higher than that before shock.. The endotoxin level 24 h following resuscitation was the highest, and markedly higher than that at the end of shock. Conclusion: The traumatic shock and resuscitation are capable of causing intestinal immunosuppression and endotoxemia.