摘要
目的制备复方奥硝唑中空栓剂,并建立质量控制方法。方法以混合脂肪酸甘油酯为基质制备中空栓剂;采用等吸收-双波长法同时测定其主药奥硝唑和左氧氟沙星的含量;对制剂进行卫生学、刺激性及稳定性等试验。结果奥硝唑和左氧氟沙星的平均回收率(n=9)分别为99.7%,100.2%,其他各项检查均符合栓剂的有关规定。结论本制剂制备工艺简单,性质稳定,质量可控。
OBJECTIVE To prepare and establish quality control for the compound ornidazole hollow type suppository. METHODS The compound ornidazole hollow type suppository was prepared with mixable fatty acid glyceride as basic;The contents of ornidazole and levofloxacin were determined by equivalent absorption dual-wavelength method;The tests of hygienic, stimulation and stability were carried out. RESULTS The average recovery of ornidazole and levofloxacin were 99.7% （ n = 9 ）, 100.2% （ n = 9 ） , other tests accord with the standard of suppository. CONCLUSION The preparation of theHollow Suppository is simple. And its quality can be well controlled.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2009年第3期224-226,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
奥硝唑
左氧氟沙星
中空栓
质量控制
ornidazole
levofloxacin
hollow suppository
quality control
