皮肤浆细胞增多症

A case of cutaneous plasmacytosis

报告1例皮肤浆细胞增多症。患者男,42岁。皮损表现为淡红褐色斑块及结节,累及头面部、躯干、腋窝及腹股沟。血IgG及IgA增高。皮损组织病理检查示真皮血管周围以成熟浆细胞为主的浸润。免疫组化检查κ和入轻链均阳性,证实浸润的浆细胞为多克隆增殖。诊断:皮肤浆细胞增多症。该病需与其他浆细胞增多性疾病相鉴别。

To report a case of cutaneous plasmacytosis, The patient was a 42-year-old man, presented with disseminated reddish-brown plaques and nodules on the head, face, trunk, axillary space, inguinal groove, etc. The serum level of IgG and IgA was higher than normal. Histopathologically, mature plasma cells perivascular infiltrate were observed mainly in the dermis. Polyclonality of infiltrating plasma cells with coexistence of both kappa and gamma chain-positive cells can he demon- strated with immunohistoehemistry. The diagnosis was established by pertinent laboratory findings. Other conditions resulting in plasma cell proliferation should be ruled out.