摘要
目的探讨心房颤动(房颤,AF)患者血液中血管性血友病因子(vWF)水平变化及其临床意义。方法持续性AF患者39例,根据超声检查分为血栓阳性(22例)和血栓阴性(17例)两组,另选窦性心律组和正常对照组各20例。采用酶联免疫吸附双抗体夹心法(ELISA)测定血浆vWF水平。结果vWF水平血栓阳性组明显高于其他组(P<0.05),Logistic回归分析显示左房内径和vWF水平是AF患者血栓形成的独立危险因素(P<0.05)。结论vWF水平是AF患者血栓形成的独立危险因素。
Objective To investigate the clinical significance of von Willebrand factor（vWF） in patients with atrial fibrillation（AF）. Methods Thirty-nine patients with persistent AF were divided into thrombosis positive group （P） and thrombosis negative group （N） according to the results of transthoracic and transesophageal echocardiography. Sinus rhythm group （20 patients with various heart disease and sinus rhythm） and normal control subjects （20 persons without any diseases） were also included in this study. Plasma levels of vWF were measured by enzyme linked immunosorbent assay（ELISA）. Results The level of vWF was higher in group P than that in the other groups （P〈0.05）. Left atrial diameter and level of vWF were independently associated with thrombosis in the left atrium in patients with AF （P〈0.05）. Conclusion The level of vWF is an independent risk factor for left atrial thrombosis in patients with AF.
出处
《江苏医药》
CAS
CSCD
北大核心
2009年第4期385-386,共2页
Jiangsu Medical Journal
