慢性乙型肝炎患者血清瘦素表达及临床意义

Expression and clinical significance of serum leptin in patients with chronic hepatitis B

目的观察慢性乙型肝炎(慢乙肝)患者血清瘦素表达水平及其在发病、进展中的意义。方法65例慢乙肝组、肝硬化组患者和15名健康体检(对照)组,酶联免疫吸附试验(ELISA)检测血清瘦素水平,全自动生化分析仪检测肝功能。结果血清瘦素水平两肝病组明显高于对照组(P<0.01),三组女性均明显高于男性(P<0.01);肝病患者随着肝功能好转,血清瘦素水平显著下降(P<0.01)。结论慢乙肝患者血清瘦素水平随病情程度加重趋于升高,随着肝功能好转而降低,可作为疗效观察及预后判断的指标。女性瘦素水平显著高于男性。

Objective To investigate the expression and clinical significance of serum leptin in patients with chronic hepatitis B（CHB）. Methods The levels of serum leptin in 65 CHB（group CHB）,cirrhosis（group LC） induced by hepatitis B patients and 15 healthy volunteers（group C） were detected by enzyme-linked immunosorbent assay （ELISA）. Liver function was examined by automatic biochemistry analyzer. Results Serum leptin level in group CHB and LC was significantly higher than that in group C （P〈0. 01）. Leptin level of female was significantly higher than that of male in all three groups （P〈0.01）. Serum leptin level in groups of CHB and LC significantly decreased along with the improvement of liver function （P〈0.01）. Conclusion Expression levels of serum teptin in the CHB patients increase with the severity of hepatic disease, which may be considered as an index for evaluating therapeutic effect and prognosis. Serum leptin level is higher in female than that in male.