酚妥拉明、去氧肾上腺素对兔离体气管平滑肌收缩力的影响

Efficts of phentolamine and phenylephrine on the contraction of isolated rabbit tracheal smooth muscle

目的观察酚妥拉明及去氧肾上腺素对离体气管平滑肌张力的影响。方法观察一定剂量的酚妥拉明、去氧肾上腺素对静息状态下离体兔气管平滑肌张力的影响;用电刺激诱发兔离体气管平滑肌收缩,观察一定剂量的酚妥拉明、去氧肾上腺素对其的影响。结果酚妥拉明0.66mmol/L及去氧肾上腺素1.23 mmol/L对静息状态气管平滑肌无直接收缩作用(P>0.05)。酚妥拉明0.66 mmol/L可显著抑制电刺激诱发的气管平滑肌收缩(P<0.01)。去氧肾上腺素1.23 mmol/L使电刺激兔离体气管平滑肌收缩力略有增加(P>0.05)。结论酚妥拉明对电刺激诱发兔离体气管平滑肌收缩力有显著的抑制作用;去氧肾上腺素则无明显影响。

Objective To observe the effects of phentolamine and phenylephrine on the isolated tracheal smooth muscle in rabbits. Methods The effects of phentolamine and phenylephrine on the tension of isolated rabbits tracheal smooth muscles in quiescent condition and in electrical stimulation were measured. Results Phentolamine 0. 66 mmol/L and phenylephrine 1.23 mmol/L did not affect the tension of isolated tracheal smooth muscle in quiescent condition. Phentolamine 0. 66 mmol/L markedly decreased the tension of isolated tracheal smooth muscle induced by electrical field （P〈0. 01）, but phenylephrine 1.23 mmol/L increased the tensions slightly （P〉0.05）. Conclusion Phentolamine can inhibit the tension of isolated tracheal smooth muscles induced by electrical field in rabbits, but phenylephrine has no effect on that.