清栓酶治疗脑血栓后对血液流变学效果的研究

Study of Effect on Hemorheolgy in Cerebral Thrombosis After Qingshuanmei Therapy

作者研究目的是观察脑血栓病人在用清栓酶治疗前后的血液流变学变化，并探讨其药物的作用机制。观察分为两组：Ａ组脑血栓病人３０例，Ｂ组为健康献血员２５例。脑血栓病人组采用清栓酶治疗。治疗前后，采集静脉血做血液流变学检查。结果表明，治疗后红细胞电泳时间（ＥＥＴ）、血沉（ＥＳＲ）、血沉Ｋ值（ＥＳＲ－Ｋ）和低切变率全血粘度（ηｂＬ）明显降低（Ｐ＜０．０５～０．０１），尤其是白细胞滤过揩数（ＦＩ）的显著降低，可改善血液微循环和增加缺血区的再灌注而获疗效。其药物治疗效果与改善血液流变相一致。作者对２５例健康人进行研究的结果表明清栓酶有轻度促凝现象。

The purpose to do this study was to observe hemorheolgy change in patiants suffering from cerebral thrombosis before and after Qingshuanmei (QSM) treatment, and explore pharmacologic mechaism after medicine. A group consisting of 30 patients were treated with QSM, 0.75u in 20 days. Changes of hemorheolgy before and after therapy were compared. The study showed that ESR, ESR K, erythrocyte electrophoretic time (EET), low shear rate viscosity were decreased (P<005～001) significantly especially FI, but erythrocyte deformability and leukocyte filterability increased (P>005～001) significantly after treatment. Thus, these changes mean improvement of the microcirculation and increased reperfusion of ischemic areas. The results from treatment of medicine were in compliance with hemoreheogy. In addition, this study in vivo, or in vitro test, indicated that there was appearance of a slight coagulants besides the above mentioned effects.