系统性红斑狼疮伴肝、肾损害时血浆P选择素测定意义

Significance of plasma P-selectin detection in systemic lupus erythematosus with liver and kidney lesions

为探讨粘附分子P选择素在系统性红斑狼疮（SLE）发病中的作用，本文采用ELISA法检测SLE患者血浆P选择素含量。结果表明30例患者血浆P选择素平均水平较正常对照明显升高（P＜0．01）。其中SLE伴肝、肾损害者的血浆P选择素显著高于不伴有肝、肾损害者（P＜0．01），后者与正常对照组相比，也有显著差异。此外，SLE患者血浆P选择素变化与血沉（ESR）呈正相关（r＝0．467，P＜0．01）；但与CRP（C反应蛋白）之间无相关性（P＞0．05）。表明P选择素可能参与SLE的发生和发展，其检测对判断疾病进展和活动转归等具有重要意义。

Cell adhesion molecules are involved in leukocyte-leukocyte, leukocyte-endothelium and plateletendothelium interactions, important events in the pathogenesis of autoimmune diseases. To investgate therole of P-selectin in systemic lupus erythematosus (SLE), we detected plasma P-selectin in patients withSLE by ELISA. The results showed that plasma P-selectin level was significantly increased in 30 patientsthan controls (P<0. 01 ). There were an significant increase in patients with liver and kidney lesions thanthat without liver and kidney lesions (P<0. 01). Furthermore ) plasma P-selectin level in patients with SLEwere correlated with ESR (r=0. 467,P<0. 01) and were not related to CRP (P>0. 05). P-selectin plays arole in the pathogenesis of SLE and plasma P-selectin detection may be useful for evaluating the progress ofSLE.