寄生虫烯醇酶的功能研究进展

Research progress on the functions of enolase in parasites

烯醇酶不仅是糖酵解的关键酶，还具有其他多种功能，不仅存在于细胞质中，还在细胞膜、细胞核中存在。它在真核细胞和原核细胞表面具有纤溶酶原受体的功能，参与病原体与宿主纤溶酶原的结合，与病原体对宿主的侵袭和感染有关，是一个潜在的保护性抗原；它在细胞核内参与了基因转录的调控过程，具备热激蛋白（heat shock protein）的功能。该文着重对烯醇酶在寄生虫感染宿主、寄生虫与宿主相互作用的研究进展作简要综述，介绍烯醇酶在一系列生物学和疾病过程中结构与功能的相互关系。

The enolase, not only is a key enzyme of glycolysis, but also has a variety of functions, existing in the cytoplasm, cell membrane as well as the nucleus. It acts as receptors for the host plasminogen existing in eukaryotic and prokaryotic cell surface, involved in the invasion and infection of pathogens to hosts, so it is a potential protective antigen. In nuclei it is involved in the regulation of gene transcription process, functioning as heat shock protein. This review focused on the research progress on the role of enolase in parasite infection, interaction between parasite and host, and introduced the mutual relations between the structure and the function of enolase in a series of biology and disease process.