心力衰竭患者血浆神经肽Y、神经降压素水平变化

The changes of plasma neuropeptide Y and neurotensin levels in patients with heart failure

目的观察心力衰竭患者血浆神经肽Y（NPY）、神经降压素（NT）水平的变化，并探讨其临床意义。方法选择76例心力衰竭患者（心力衰竭组），应用彩色超声心动图检查其心脏结构和功能，计算左室射血分数（IJVEF）。应用放射免疫分析法检测患者血浆NPY、NT水平，并与28例健康者（对照组）进行比较。结果（1）心力衰竭组血浆NPY水平[（159．7±56．3）ng／L]高于对照组[（120．8±51．9）．gel]，P＜0．05；而NT水平[（69．5±29．6）ng／L]低于对照组[（99．1±19．3）ng／L]，P＜0．01。（2）随着心功能损害的加重，NPY水平逐渐升高，而NT水平逐渐降低。（3）心力衰竭患者LVEF与血浆NPY水平呈负相关（r=-0．31，P＜0．05），与NT水平呈正相关（r=0．28，P＜0．05）。血浆NPY与NT水平呈负相关（r=-0．26，P＜0．05）。结论心力衰竭患者血浆NPY水平升高，而NT水平降低，存在平衡失调，这种平衡失调可能参与了心功能损害的过程。监测血浆NPY、NT水平变化可评价心力衰竭患者病情及预后。

Objective To observe the changes of plasma neuropeptide Y （NPY） and neurotensin （NT） levels in patients with heart failure and investigate their clinical significance. Methods The levels of plasma NPY, NT of 76 patients with heart failure and 28 normal controls were determined by radioimmunoassay （RIA）. The color echocardiogram was used to evaluate the cardiac structure, function and left ventricular ejection fraction （ INEF ）. Results The level of plasma NPY in patients with heart failure [ （ 159.7 ± 56.3 ） ng/L] was higher than that in normal controls [（120.8 ± 51.9） ng/L ] （P 〈 0.05 ）, the level of plasma NT [ （69.5 ＋ 29.6 ） ng/L ] was significantly lower than that in normal controls [ （99.1 ± 19.3 ） ng/L ] （P 〈 0.01 ）. Following the severity of heart failure, the level of plasma NPY increased, and the level of plasma NT decreased. The level of LVEF had negative correlative relationship with the level of plasma NPY （r = -0.31, P 〈 0.05 ） and positive correlative relationship with the level of plasma NT （r = 0.28, P 〈 0.05 ）. The level of plasma NPY and NT in patients with heart failure had negative correlative relationship （r = -0.26, P〈 0.05 ）. Conclusions The levels of plasma NPY, NT in patients with heart failure are unbalanced. This unbalance may participate in the damage of cardiac function.