摘要
通过对真核生物142个基因的部分启动子序列的折叠模型进行分析研究,结果表明,这些基因的TATA框在折叠结构模型中所表现的茎环结构特征有利于与反式作用因子和RNA聚合酶的识别及其相互作用。
おhe secondary-structural features of TATA box is important for the initial process of RNA transcription in eukaryotic. After observing the secondary-structures of 142 genes' promotor sequences,we proposed this structural model of the stems and loops for the nucleotide sequences of the TATA box in eukaryotic. Our results suggested that the structural features of TATA box in structural models of the stems and loops were closely associate with the recognition and interaction of the transcription factor and RNA polymerase. We got a consistent result by comparing with the corresponded secondary-structural features of E. coli. Among the distribution of hairpin,interloop,and single strand there was a difference.