摘要
目的:制备去甲斑蝥素骨架型缓释微丸,并对其体外释药情况进行研究。方法:采用挤出-滚圆技术制备去甲斑蝥素骨架型缓释微丸,研究了处方因素对去甲斑蝥素骨架型缓释微丸的制备和释放度的影响,采用正交试验,通过综合打分法,多元回归分析确定最优处方。结果:以微晶纤维素1.98 g、乙基纤维素∶硬脂酸(1∶1.5)、黏合剂1%羟丙甲纤维素13 mL,烘干制得的去甲斑蝥素骨架型缓释微丸具有较好的缓释效果。结论:采用挤出-滚圆技术,通过缓释材料制备的去甲斑蝥素骨架型缓释微丸,其体外释药缓慢、持续、平稳。
Objective： To prepare norcantharidin sustained-release pellets, and investigate the mechanism of drug release in vitro. Methods： Extrusion-spheronization method was used to prepare the pellets. The effects of process variables and formulation variables on pellet preparation and drug release were investigated. Results： The main factors affecting the release rate were the type of material applied and the temperature of drying. Release of the drug from pellets was in accordance with Higuchi equation. Conclusion： The method and the formulation are successful in providing slow and steady release of norcantharidin from sustained-release pellets.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2009年第6期549-552,共4页
Chinese Journal of New Drugs
基金
江苏省科技厅社会发展项目资助(BS200522)
苏州大学大学生创新性实验计划项目资助(57315854)
关键词
去甲斑蝥素
缓释微丸
体外释放
正交试验
多元回归分析
norcantharidin
sustained-release pellets
release in vitro
orthogonal experiment
multiple regression analysis
