拐芹化学成分的研究

Studies on chemical constituents from roots of Angelica polymorpha

目的:研究拐芹Angelica polymorpha根化学成分。方法:采用硅胶柱色谱进行分离纯化,通过理化常数测定结合谱学分析鉴定化合物的结构。结果:从拐芹中分离并鉴定了14个化合物,分别为5-羟基-2-[(当归酰氧基)甲基]呋喃[3′,2′:6,7]骈色原酮(5-hydroxy-2-[(angeloyloxy)methyl]furan[3′,2′∶6,7]chromone,1),二十八烷酸(octacosanoic acid,2),异欧前胡素(isoimperatorin,3),3′S-(-)-O-乙酰基亥茅酚[3′S-(-)-O-acetylhamaudol,4),佛手柑内酯(bergapten,5),异氧化前胡内酯(iso-oxypeucedanin,6),β-谷甾醇(β-sitosterol,7),拐芹色原酮(angeliticin A,8),石当归素(saxalin,9),栓翅芹烯醇(pabulenol,10),去甲基丁香色原酮(noreugenin,11),水合氧化前胡(oxypeucedaninhydrate,12),胡萝卜苷(daucosterol,13),蔗糖(sucrose,14)。结论:化合物1为新色原酮结构,命名为紫金砂色原酮A(polymorchromone A)。化合物2,4,11,13,14为首次从该植物中分离得到。

Objective： To investigate the chemical constituents of the roots of Angelica polymorpha. Method： Sihca gel column chromatography was employed for the isolation and purification of chemical constituents. The structures were identified on the basis of spectral data and chemical evidence. Result： Fourteen compounds were isolated and identified as follows, 5-hydroxy-2-[ （angeloyloxy） methyl] furan [3＇, 2＇： 6, 7] chromone （1）, octacosanoic acid （2）, isoimperatorin （3）, 3＇S-（-）-O-acetylhamaudol （4）, bergapten （5）, iso-oxypeucedanin （ 6 ） , β-sitosterol （ 7 ）, angeliticin A （ 8 ） , saxalin （ 9 ） , pabulenol （ 10 ）, noreugenin （ 11 ）, oxypeucedanin hydrate （12）, daucosterol （13）, sucrose （14）. Conclusion： Compound 1 is a new chromone, named polymorchromone A. Compounds 2, 4, 11, 13, 14 were isolated from A. polymorpha for the first time.