强化SOD刺梨汁对铅中毒大鼠、小鼠的治疗作用

Therapeutic effect of Cili juice enriched with SOD on lead poisoning in rats and mice

目的：观察强化ＳＯＤ刺梨汁（简称ＳＯＤ刺梨汁）对铅中毒动物的驱铅作用，及其对铅中毒动物体内超氧化物歧化酶（ＳＯＤ）、过氧化脂质（ＬＰＯ）和免疫功能的影响。方法：用大鼠、小鼠建立铅中毒模型，检测ＳＯＤ刺梨汁对大鼠的排铅量、ＳＯＤ活性和ＬＰＯ含量，以及小鼠免疫功能的变化，并与临床常用药物ＥＤＴＡ进行比较。结果：ＳＯＤ刺梨汁能显著地增加铅中毒大鼠铅排出量。而且能显著地升高ＳＯＤ活性和减少ＬＰＯ含量，明显地增强铅中毒小鼠的免疫功能。这些作用是ＥＤＴＡ所没有的。结论：ＳＯＤ刺梨汁对铅中毒动物比ＥＤＴＡ具有更为全面的治疗作用。

OBJECTIVE: To observe the effects of Cili juice enriched with SOD (CLJES) on lead excretion, activity of superoxide dismutase (SOD) in erythrocytes, plasma lipid peroxidation (LPO) and immune function in experimental lead poisoning animals. METHODS: Lead poisoning models were made in rats and mice. The effects of CLJES on lead excretion, SOD activity, LPO concentration in rats and immune functions in mice were determined and compared with those of conventional EDTA treatment. RESULTS: CLJES significantly increased lead excretion. Furthermore it significantly increased SOD activity, reduced LPO concentration in rats with lead poisoning and enhanced immune function in lead loaded mice, however EDTA had no such actions. CONCLUSION: CLJES might exert a wider range of therapeutic effects on lead poisoning than EDTA.