β-羧乙基锗倍半氧化物和还原型谷胱甘肽及维生素B_1配伍抗氧化作用

Antioxidative effect of βcarboxyethyl germanium sesquioxide (Ge132) combined with GSH and VB1 in vivo

目的：探讨β羧乙基锗倍半氧化物（Ｇｅ１３２）与还原型谷胱甘肽（ＧＳＨ）和维生素Ｂ１（ＶＢ１）联合应用在体内抗氧化的作用。方法：观察这些药物对乙醇诱发大鼠氧应激态作用下的抗氧化酶活性变化。结果：肝线粒体总超氧化物歧化酶和铜锌超氧化物歧化酶活性，乙醇组与正常对照组比较，其活性显著下降（Ｐ＜０．０５）；乙醇＋Ｇｅ１３２＋ＶＢ１＋ＧＳＨ组与乙醇组比较，肝线粒体酮锌超氧化物歧化酶（Ｃｕ，ＺｎＳＯＤ）活性上升（Ｐ＜０．０５）。结论：Ｇｅ１３２与ＧＳＨ和ＶＢ１联合应用对乙醇导致的自由基损伤有协同保护作用。

OBJECTIVE: To examine the antioxidative effect of βcarboxyethyl germanium sesquioxide (Ge132) combined with GSH and VB1 in vivo. METHODS: The effects of these drugs on rats under oxidative stress induced by ethanol were investigated by observing the activities of superoxide dismutase (SOD) in liver mitochondria and brain, and the activity of glutathion peroxidase (GSHPx) in serum in the rats. RESULTS: The activity of CuZnSOD in liver mitochondria decreased in the rats of ethanol group compared with that of the control group (P<0.05), and increased in the ethanol +Ge132 +VB1 +GSH group compared with ethanol group (P<0.05). CONCLUSION: Ge132 could protect from damage caused by free radical in ethanol feeding rats. There is a coordinated effect by combined administration of Ge132 with GSH and VB1.