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Toll样受体4的研究进展和临床意义 被引量：8

Advancement and clinical significance of toll-like receptor 4
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摘要 Toll样受体(TLR)是天然免疫受体家族。越来越多的研究证实,其中的Toll样受体4(TLR4)与多种疾病的发生、发展相关,有着重要的临床意义。以下就近年来对TLR4的一些相关研究进展和临床意义作一综述。 Toll-like receptors are regulators of innate immune responses. One of them, the Toll-like receptor 4 （TLR4） has been proved to be associated with the cause and progress of many diseases by more and more researches. This review describes the relevant research progress and clinical significance of tolllike receptor 4.
作者 张乐逸 张宇飞 嵇武
机构地区 南京大学医学院临床学院(南京军区南京总医院)解放军普通外科研究所
出处 《肠外与肠内营养》 CAS 北大核心 2009年第2期123-126,共4页 Parenteral & Enteral Nutrition
基金 南京军区医学科学技术研究"十一.五"计划课题资助(06MA112)
关键词 TOLL样受体4 信号转导 Toll-like receptor 4 Signal transduction
分类号 R392.1 [医药卫生—免疫学]
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参考文献22

  • 1Parker LC,Prince LR,Sabroe I. Translational Mini-Review Series on Toll-like Receptors:Networks regulated by Toll-like receptors mediate innate and adaptive immunity [ J ]. Clin Exp Immunol, 2007,147 (2) : 199-207.
  • 2Medzhitov R, Preston2Hurburt P, Janeway CA. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity [ J ]. Nature, 1997,388 ( 6640 ) :394-397.
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  • 5嵇武,李宁.Toll样受体与临床疾病关系的研究进展[J].中国误诊学杂志,2007,7(16):3709-3711. 被引量：7
  • 6Franchimont D, Venneire S, El Housni H, et al. Defieient hostbacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis[J]. Gut ,2004,53(7) :987-992.
  • 7Chochi K, Ichikura T, Kinoshita M, et al. tlelieobaeter pylori augments growth of gastric cancers via the lipopolysaccbaride-toll-like receptor 4 pathway whereas its lipopolysaccharide attenuates antitumor activities of human mononuelear cells [ J ]. Clin Cancer Res, 2008,14 ( 10 ) :2909 -2917.
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二级参考文献12

  • 1Gibson FC,Yumoto H,Takahashi Y,et al.Innate immune signaling and porphyromonas gingivalis-accelerated atherosclerosis[J].J dent Res,2006,85(2):106-121.
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  • 4Lin Y,Zeng Y,Zeng S,et al.Potential role of toll-like receptor 3 in a murine model of polyinosinic-polycytidylic acid-induced embryo resorption[J].Fertil-Steril,2006,85(Suppl 1):1125-1129.
  • 5Thornley TB,Brehm MA,Markees TG,et al.TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts[J].J Immunal,2006,176(3):1561-1570.
  • 6Obhrai J,Goldstein DR.The roll of toll-like receptors in solid organ transplantation[J].Transplantation,2006,81(4):497-502.
  • 7Romagne F.Current and future drugs targeting one class of innate immunity receptors:the Toll-like receptors[J].Drug Discov Today,2007,12(1-2):80-87.
  • 8Ishihara S,Rumi MA,Ortega-Cava CF,et al.Therapeutic targeting of toll-like receptors in gastrointestinal inflammation[J].Curr Pharm Des,2006,12(32):4215-4228.
  • 9Parker LC,Prince LR,Sabroe I.Translational Mini-Review Series on Toll-like Receptors:Networks regulated by Toll-like receptors mediate innate and adaptive immunity[J].Clin Exp Immunol,2007,147(2):199-207.
  • 10Delbridge LM,O'riordan MX.Innate recognition of intracellular bacteria[J].Curr Opin Immunol,2007,19(1):10-16.

共引文献6

同被引文献79

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二级引证文献45

肠外与肠内营养
2009年 第2期

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