期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

沙利度胺对胶原诱导性关节炎大鼠血管内皮生长因子肿瘤坏死因子-α表达的影响 被引量：4

原文传递
导出
摘要 本研究通过建立胶原诱导型关节炎（collagen induced arthritis，CIA）大鼠模型，采用酶联免疫吸附试验（ELISA）、免疫组织化学等方法，研究血管内皮生长因子（VEGF）及肿瘤坏死因子（TNF—α）在血清及滑膜中动态表达、细胞因子与关节炎症及滑膜微血管密度（MVD）相关性及沙利度胺对上述变化的影响，探讨不同剂量沙利度胺作用及可能机制，试图为沙利度胺在类风湿关节炎（rheumatoid arthritis，RA）新靶点治疗——阻断血管生成方面提供实验依据。
作者 刘爱京 刘曦 邵福灵 靳洪涛 刘晓雷 郭欣 潘凌
机构地区 河北医科大学第二医院免疫风湿科 河北医科大学第二医院血液科 河北医科大学第二医院检验科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2009年第4期275-278,共4页 Chinese Journal of Rheumatology
基金 河北省科技厅资助项目（072761983）
关键词 血管内皮生长因子 肿瘤坏死因子-Α 沙利度胺 关节炎大鼠 胶原诱导性 胶原诱导型关节炎 酶联免疫吸附试验 免疫组织化学
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献8

  • 1刘爱京,潘崚,王崇,刘曦,邵福灵,靳洪涛,刘晓雷.沙利度胺影响实验性关节炎大鼠肿瘤坏死因子-α及血红蛋白的研究[J].中华风湿病学杂志,2008,12(1):39-44. 被引量：4
  • 2Taylor PC. Serum vascular markers and vascular imaging in assessment of rheumatoid arthritis disease activity and response to therapy. Rheumatology, 2005, 44: 721-728.
  • 3Cha HS, Bae EK, Koh JH, et al. Tumor necrosis factor-alpha induces vascular endothelial growth factor-C expression in rheumatoid synoviocytes. J Rheumatol, 2007, 34: 16-19.
  • 4Lainer DT, Brahn E. New antiangiogenic strategies for the treatment of proliferative synovitis. Expert Opin Investig Drugs, 2005, 14: 1-17.
  • 5Du W, Hattori Y, Hashiguchi A, et al. Tumor angiogenesis in the bone marrow of multiple myeloma patients and its alteration by thalidomide treatment. Pathol Int, 2004, 54: 285-294.
  • 6Lehman TJ, Schechter SJ, Sundel RP, et al. Thalidomide for severe systemic onset juvenile rheumatoid arthritis: a multicenter study. J Pediatr, 2004, 145: 856-857.
  • 7Li X, Liu X, Wang J, et al. Thalidomide down-regulates the expression of VEGF and bFGF in cisplatin-resistant human lung carcinoma cells. Anticancer Res, 2003, 23: 2481-2487.
  • 8Yabu T, Tomimoto H, Taguchi Y, et al. Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate. Blood, 2005, 106: 125-134.

二级参考文献14

  • 1Trentham DE, Townes AS, Kang AH, et al. Autoimmunity to type Ⅱ Collagen: An experimental model of arthritis. J Exp Med, 1977, 146: 857-868.
  • 2Wakamatsu K, Nanki T, Miyasaka N, et al. Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells. Arthritis Res Ther, 2005, 7: 1348-1359.
  • 3Baharav E, Mor F, Halpern M, et al. Lactohacillus GG hacteria ameliorate arthritis in Lewis rats. J Nutr, 2004, 134: 1964-1969.
  • 4Lee DM, Weinblatt ME. Rheumatoid arthritis. Lancet, 2001, 358: 903-911.
  • 5Boyce BF, Li P, Yao Z, et al. TNF-alpha and pathologic bone resorption. Keio J Med, 2005, 54: 127-131.
  • 6Papadaki HA, Heraklis D. Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: improvement following anti-tumor necrosis factorantibody therapy. Blood, 2002, 100: 474-482.
  • 7Kavanaugh A, St Clair EW, McCune W J, et al. Chimeric anti-tumor necrosis factor-alpha monoclonal antibody treatment of patients with rheumatoid arthritis receiving methotrexate therapy. J Rheumatol, 2000, 27: 841-850.
  • 8Papadaki HA, Heraklis D. Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect. Blood, 2002, 99: 1610-1619.
  • 9Asai F, Oshima T. Recombinant human erythropoietin, but not iron supplementation, improves anemia in rats with adjuvant-induced arthritis. Jpn J Pharmaeol, 1991, 57: 291-298.
  • 10Carbonell MT, Saiz MP, Marti MT, et al. Iron mobilization in three animal models of inflammation. Rev Esp Fisiol, 1989, 45: 163-170.

共引文献3

同被引文献25

  • 1Dong, Zhi-Zhen,Yao, Deng-Fu,Wu, Wei,Yao, Min,Yu, Hong-Bo,Shen, Jun-Jun,Qiu, Li-Wei,Yao, Ning-Hua,Sai, Wen-Li,Yang, Jun-Ling.Delayed hepatocarcinogenesis through antiangiogenic intervention in the nuclear factor-kappa B activation pathway in rats[J].Hepatobiliary & Pancreatic Diseases International,2010,9(2):169-174. 被引量：31
  • 2王斌,陈敏珠,徐叔云.大鼠滑膜细胞的分离和培养[J].中国药理学通报,1994,10(1):73-74. 被引量：48
  • 3唐雪梅,李秋,蒋丽萍,赵晓东,王莉佳,王墨,杨锡强.TGF-β1、VEGF在儿童原发性肾病综合征中的表达及其临床意义[J].临床儿科杂志,2006,24(4):270-275. 被引量：2
  • 4周小妹,徐建华,李兴锐,等.甲氨蝶呤代谢相关酶的基因多态性及其临床应用相关性研究进展,2008,2:124-126.
  • 5Maeda T,Hirayama M,Kobayashi D,et al.Mechanism of theregulation of organic cation/carnitine transporter 1(SLC22A4)by rheumatoid arthritis-associated transcriptionalfactor RUNX1and inflammatory cytokines[J].Drug MetabDispos,2007,35(3):394-401.
  • 6Pap T,van der Laan WH,Aupperle KR,et al.Modulation offibroblast-mediated cartilage degradation by articularchondrocytes in rheumatoid arthritis[J].Arthritis Rheum,2000,43(11):2531-2536.
  • 7Kim WU,Kang SS,Yoo SA,et al.Interaction of vascularendothelial growth factor 165 with neuropilin-1 protectsrheumatoid synoviocytes from apoptotic death by regulatingBcl-2expression and Bax translocation[J].J Immunol,2006,177(8):5727-5735.
  • 8Edwards JC.Fibroblast biology.Development anddifferentiation of synovial fibroblasts in arthritis[J].ArthritisRes,2002,2(5):344-347.
  • 9Alvaro-Gracia JM,Yu C,Zvaifler NJ,et al.Mutual antagonismbetween interferon-gamma and tumor necrosis factor-alpha onfibroblast-like synoviocytes:paradoxical induction of IFN-gamma and TNF-alpha receptor expression[J].J ClinImmunol,1993,13(3):212–218.
  • 10Davis LS.A question of transformation:the synovial fibroblastin rheumatoid arthritis[J].Am J Pathol,2003,162(5):1399-1402.

引证文献4

二级引证文献15

中华风湿病学杂志
2009年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部