哮喘病人MΦ之ADCC效应及非特异性吞噬功能

PERIPHERAL BLOOD MONOCYTES/MACROPHAGES DERIVED FROM ASTHMA PATIENTS MEDIATE ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY (ADCC) AND NONSPE CIFIC PHAGOCYTOSIS

体外测定了２４例支气管哮喘急性发作期病人和３４例健康人外周血单核／巨噬细胞的ＡＤＣＣ效应及非特异性吞噬功能。结果表明：自然状态下，哮喘病人单核／巨噬细胞ＡＤＣＣ作用及非特异性吞噬功能与健康对照无差异；但经ＬＰＳ活化后，哮喘组ＡＤＣＣ效应明显高于健康对照组，而非特异性吞噬功能减弱，低于健康对照，两者差异均显著（Ｐ＜０．０５）。提示：哮喘病人单核／巨噬细胞ＡＤＣＣ作用增高可能参与了病变局部变态反应性炎症病灶的形成。

Both the antibodydependent cellular cytotoxicity(ADCC) and the nonspecific phagocytosis exerted by peripheral blood monocytes/macrophages were observed in 24 patients with bronchial asthma at acute phase compared with health controls Results showed that nonstimulated monocytes/macrophages in patients with asthma had the same two activities as that in health individualsHowever,significant elevation of ADCC activity and decrease of nonspecific phagocytic activity were measured in LPSstimulated monocytes/macrophages from asthma patients as compared with that in health controlsThese results indicated that the elevation of ADCC activity in patients with asthma played a role in the formation of the inflammatory focus in asthma