粒细胞集落刺激因子与血液病

Granulocyte colony-stimulating factor and hematonosis

粒细胞集落刺激因子是一种糖基化的多肽链细胞生长因子,能特异地调节粒系祖细胞的增殖与分化,并能增强成熟中性粒细胞的功能。粒细胞集落刺激因子功能的发挥有赖于与效应细胞表面的特异性受体的结合。随着基因克隆技术的发展,粒细胞集落刺激因子重组产品已广泛应用于临床,为血液系统疾病的治疗提供了有力手段。目前在临床上广泛用于白细胞减少性疾病。近年来在化疗基础上联用粒细胞集落刺激因子的预激方案也取得良好疗效,为难治、复发、老年急性髓系白血病的治疗创造了机会。目前,粒细胞集落刺激因子是临床上应用最成功的几种造血调控因子之一。

Granulocyte colony-stimulating factor is a glycosylated polypeptide chain cell growth factor that can promote proliferation and differentiation of myeloid progenitors and induce maturation of these cells toward terminally differentiated neutrophils. Granulocyte colony-stimulating factor which functions and effects depend on the combination with specific receptor on the surface of effector cells. With the development of gene cloning technology, ganulocyte colony-stimulating factor recombinant products have been widely used in clinic to provide effective means for the treatment of leucopenia,ln recent years we find the therapy of chemotherapeutics combining with granulocyte colony-stimulating factor is effective in refractory/relapsed/elderly cases of acute leukaemia. Currently, granulocyte colony-stimulating factor is one of important and successful hematopoietic cytokines in clinic.