微生物发酵生产透明质酸研究进展

Progress on Optimization of Fermentation Conditions of Hyaluronic Acid

对微生物发酵法制备透明质酸的菌种选育、工艺优化等方面的研究进展进行了综述,重点讨论了温度、pH值、搅拌转速,发酵时间以及培养方式等发酵条件对透明质酸产量和分子质量的影响,并对微生物发酵法生产透明质酸的发展前景进行了展望,旨在为微生物发酵法生产透明质酸的发酵条件的研究提供参考和借鉴。

This article reviews the recent progress of the mutagenesis on strains and fermentation conditions for producing hyaluronic acid, and discusses the effects of temperature, pH, agitation and time of fermentation conditions on hyaluronic acid yield and its molecular weight, and presents the prospects of its application as a guidance to the fermentation of hyaluronic acid.