摘要
匹伐他汀(pitavastatin)是新一代HMG-CoA还原酶抑制剂,能显著降低低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)及升高高密度脂蛋白胆固醇(HDL-C),药动学性质优良,具有肝细胞选择性,且毒性低,安全性好,具有抗动脉粥样硬化、促血管生成和抗炎作用。现对其药理作用、临床研究及不良反应等做一综述。
Pitavastatin is a novel,fully synthetic HMG-CoA reductase inhibitor,which can significantly reduce low-density lipoprotein cholesterol(LDL-C),triglycerides(TG),and also increase high-density lipoprotein cholesterol(HDL-C).The drug is well tolerated and safe.It not only has potent cholesterol-lowering effects,but also has anti-atherosclerotic,angiogenesis-promoting and anti-inflammatory effects by selectively acting on liver cells.In this paper,we reviewed pharmacology,pharmacotherapy and adverse reactions of pitavastatin.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2009年第5期383-386,402,共5页
Chinese Journal of New Drugs