匹伐他汀的药理作用及临床应用

Pharmacological effects and clinical application of pitavastatin

匹伐他汀(pitavastatin)是新一代HMG-CoA还原酶抑制剂,能显著降低低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)及升高高密度脂蛋白胆固醇(HDL-C),药动学性质优良,具有肝细胞选择性,且毒性低,安全性好,具有抗动脉粥样硬化、促血管生成和抗炎作用。现对其药理作用、临床研究及不良反应等做一综述。

Pitavastatin is a novel,fully synthetic HMG-CoA reductase inhibitor,which can significantly reduce low-density lipoprotein cholesterol（LDL-C）,triglycerides（TG）,and also increase high-density lipoprotein cholesterol（HDL-C）.The drug is well tolerated and safe.It not only has potent cholesterol-lowering effects,but also has anti-atherosclerotic,angiogenesis-promoting and anti-inflammatory effects by selectively acting on liver cells.In this paper,we reviewed pharmacology,pharmacotherapy and adverse reactions of pitavastatin.