两种黄体支持方法对IVF-ET术后妊娠结局的影响

Effect of two ways of luteal support on pregnant outcomes after in vitro fertilization and embryo transfer cycles

目的:探讨两种黄体支持方法对体外受精-胚胎移植(IVF-ET)术后妊娠结局的影响。方法:将2006年3～10月本中心258例IVF-ET新鲜周期术后妊娠患者按不同黄体支持方法随机分为两组:A组(104例)采用地屈孕酮+黄体酮雌激素口服进行黄体支持,B组(154例)采用黄体酮+雌激素进行黄体支持。结果:A组的流产率、异位妊娠率分别为11.5%、3.84%,B组分别为13.9%、5.19%,A组流产率和异位妊娠率均略低于B组,但差异无统计学意义;A组黄体酮用量明显多于B组(P<0.01)。结论:地屈孕酮用于IVF后妊娠的黄体支持的效果与黄体酮相同,易被患者接受,但地屈孕酮能否完全取代黄体酮对采卵后患者进行黄体支持还需进一步研究。

Objective： To explore the effect of two ways of luteal support on pregnant outcomes after in vitro fertilization and embryo transfer （ IVF - ET） cycles. Methods： 258 cases after IVF - ET from March 2006 to October 2006 were divided into 2 groups according to different ways of luteal support： group A （104 cases） was given dydrogesterone luteosterone and estrogen, group B （154 cases） was given luteosterone and estrogen. Results： The abortion rates and ectopic pregnant rates were 11.5% and 3.84% in group A, while 13.9% and 5.19% in group B, there was no significant difference; the dosage of luteosterone in group A was higher than that in group B （P 〈0. 01 ）. Conclusion： The effect of dydrogesterone on luteal support is the same as luteosterone, but further studies are needed.