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Haematological and lipid profile assays in Nigerian asthmatics 被引量:1

Haematological and lipid profile assays in Nigerian asthmatics
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摘要 Objective:To assess the haematological and lipid profile assays in asthmatics.Methods: Eighty asthmatic subjects were prospectively studied in a major referral centre serving the Niger Delta region of Nigeria for 12 months(2006-2007).Clinico-haematological and serum lipid total cholesterol(TC),triglyceride(TG),and lipoproteins concentration were analyzed after adjusting for age,cigarette smoking,alcohol ingestion,hypertension and diabetes mellitus.Results: Eighty patients(34 males and 46 females) were seen with female predominating in the various age groups(M∶F ratio,0.7∶1).Total cholesterol and low density lipoproteins-cholesterol for the asthmatics was significantly higher than the controls(P<0.000 1),while the ratio of TC∶HDL-C(high density lipoprotein-cholesterol) in asthmatics was 3.67 compared to the control value of 3.01.TC and low density lipoprotein-cholesterole(LDL-C) were significantly higher in females than the males(P<0.05).There was a combined hypertriglyceridemia(HT,>2.3mmol/L) and a significant hypercholesterolemia(HC,>5.2mmol/L) according to the Adult Treatment Panel III definition in asthmatics thereby putting them at increased risk for the development of cardiovascular disease as well as other disorders related to excess lipids.There was a significant thrombocytopenia(P<0.000 1) which may accompany allergen exposure and this persists for 24 h;that asthmatics of African descent showed a significantly increased total leucocyte count(P=0.001) similar to other studies in the Western countries.Conclusion: Hyperlipidaemia is a prevalent medical problem among asthmatics;hence screening for fasting serum lipid levels to identify those who need early intervention is recommended. Objective: To assess the haematological and lipid profile assays in asthmatics. Methods: Eighty asthmatic subjects were prospectively studied in a major referral centre serving the Niger Delta region of Nigeria for 12 months (2006-2007). Clinicoaematological and serum lipid total cholesterol (TC), triglyceride (TG), and lipoproteins concentration were analyzed after adjusting for age, cigarette smoking, alcohol ingestion, hypertension and diabetes mellitus. Results: Eighty patients (34 males and 46 females) were seen with female predominating in the various age groups ( M:F ratio, 0.7:1 ). Total cholesterol and low density lipoproteins-cholesterol for the asthmatics was significantly higher than the controls (P 〈 0. 000 1 ), while the ratio of TC:HDL-C( high density lipoprotein-cholesterol) in asthmatics was 3.67 compared to the control value of 3.01. TC and low density lipoprotein-cholesterole (LDL-C) were significantly higher in females than the males ( P 〈 0.05 ). There was a combined hypertriglyceridemia (HT, 〉 2.3mmol/L) and a significant hypereholesterolemia (HC, 〉 5.2mmol/L) according to the Adult Treatment Panel Ⅲ definition in asthmatics thereby putting them at increased risk for the development of cardiovascular disease as well as other disorders related to excess lipids. There was a significant thrombocytopenia ( P 〈 0.000 1 ) which may accompany allergen exposure and this persists for 24 h; that asthmatics of African descent showed a significantly increased total leucocyte count (P = 0.001 ) similar to other studies in the Western countries. Conclusion: Hyperlipidaemia is a prevalent medical problem among asthmatics; hence screening for fasting serum lipid levels to identify those who need early intervention is recommended.
出处 《海南医学院学报》 CAS 2009年第4期314-319,326,共7页 Journal of Hainan Medical University
关键词 哮喘 血液病学 血胆甾醇过多 高胆甾醇血 临床分析 Asthma Lipidaemia Haematological values Hypercholesterolemia
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