变形杆菌对常用抗生素的耐药性分析

Analysis of antibiotics resistance of proteus

目的:分析变形杆菌对常用抗生素的耐药性,以正确指导抗生素的合理使用。方法:采用VITEK-32全自动微生物分析仪对78株变形杆菌进行鉴定,分析其对15种常用抗菌药物的体外活性及产超广谱β-内酰胺酶(ESBLs)筛选。结果:奇异变形杆菌的产ESBLs率为18.9%(10/53),普通变形杆菌产酶率为9.5%(2/21)。三代头孢菌素、亚胺培南、丁胺卡那霉素、替卡西林+棒酸等青霉素类/β-内酰胺酶抑制剂复合剂的耐药率均低于10%。结论:实验室应加强对产ESBLs变形杆菌的检测,三代头孢菌素、亚胺培南、丁胺卡那霉素、替卡西林+棒酸等青霉素类/β-内酰胺酶抑制剂复合剂是治疗变形杆菌感染的首选药物。

Objective： Analyze the antibiotics resistance of proteus to guide the rational application of antibiotics. Methods： 78 proteus strains were identified and analyzed from the aspect of antibiotic susceptibility with the help of VITEK-32, detection of extended-spectrum β-lactamases were also conducted. Results： As for production rate of extended-spectrum β-lactamases, Proteus mirabilis was 18.9 % （ 10/53 ） , Proteus vulgaris was 9.5 % （ 2/21 ）. For antibiotic resistance rate of the proteus clinical isolates to third-generation cephalosporins,imipenem（IMP）, amikacin（AN）, ticarcillin/CA（TCC） were all less than 10%. Conclusion ： Detection of proteus species should be strengthened. Third-generation cephalosporins, imipenem（IMP） , amikaein（AN） and ticareillin/ CA（TCC） were the first choice for treating Proteus infections.