摘要
[目的]探讨肿瘤浸润性T淋巴细胞CD3-ζ链异常表达在舌癌预后预测中的价值。[方法]利用免疫组化法检测115例舌癌CD3-ζ链的异常表达,分析方法是寿命表法、Kaplan-Meier法和Spearman相关检验。[结果]CD3-ζ链异常表达(CD3-ζ减少)者占42.61%(49/115)。CD3-ζ链正常表达组患者的3、5年累积生存率分别为84.69%、82.60%,异常表达组为69.23%、66.67%(P=0.0362),单因素分析提示CD3-ζ链异常表达影响患者预后。CD3-ζ链异常表达与颈淋巴结病理阳性组患者的3、5年累积生存率最低(30.00%、30.00%),其次分别是CD3-ζ链正常表达与颈淋巴结病理阳性组(66.67%、66.67%),CD3-ζ链异常表达与颈淋巴结病理阴性组(79.32%、76.14%)患者,而CD3-ζ链正常表达与颈淋巴结病理阴性组患者的3、5年累积生存率最高(87.51%、85.01%)(P=0.0000)。[结论]肿瘤浸润性T淋巴细胞CD3-ζ链异常表达在舌癌预后评价中的有一定价值,结合颈淋巴结病理状态能更加准确地预测患者预后。
[Purposel To evaluate the prognostic significance of abnormal CD3-zeta chain (CD3-ζ) expression in tumor-infiltrating T lymphocyte (TILs) in patients with tongue carcinoma. [Methods ] The abnormal expression of CD3-ζ in 115 cases with tongue carcinoma was detected by immunohistochemically methods. Statistical methods included Life Table method, Kaplan-Meier method and Spearman test. [Results] The reduced CD3-ζ eases accounted for 42.61% (49/115). The 3-year and 5-year survival rate was 84.69%, 82.60% in the normal CD3-ζ cases, and reduced CD3-ζ cases was 66.67%, 69.23% (P=0.0362) respectively. The result of univariate analysis implied reduced CD3-ζ expression influencing the prognosis of patients. The 3-year and 5-year survival rate was the lowest (30.00%, 30.00%) in reduced CD3-ζ plus positive neck lymph node cases, followed by the normal CD3-ζ plus positive neck lymph node group (66.67%, 66.67%) and the reduced CD3-ζ plus negative neck lymph node cases (79.32%, 76.14%) respectively. The 3-year and 5-year survival rate was the highest (87.51%, 85.01%) in normal CD3-ζ plus negative neck lymph node cases (P=0.0000). [Conclusion] Reduced CD3-ζ expression in TILs plays certain role in predicting prognosis for tongue carcinoma, and more accurate if it combined with neck lymph node status.
出处
《中国肿瘤》
CAS
2009年第4期304-307,共4页
China Cancer
关键词
舌肿瘤
鳞状细胞癌
单因素分析
预后
tongue neoplasms
squamous cell carcinoma
univariate analysis
prognosis