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FLT3基因突变与白血病的关系

Relationship of FLT3 Gene Mutation with Leukemia
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摘要 FL33属于Ⅲ型受体酪氨酸激酶家族成员之一，研究表明，其在正常造血及免疫系统的发育中起重要调节作用。FLT3基因突变常见有两种，即内串联复制和点突变。FLT3在急性髓细胞白血病中有过度表达，FLT3基因的内部串联重复（FLT3-ITD）是急性髓细胞白血病最常见的基因异常。FLT3还可作为白血病基因诊断及微小残留病灶的检测标志。本文就FLT3及其突变与白血病的发生、发展及预后的关系予以综述。 FLT3 is a member of receptor tyrosine kinases type Ⅲ family, which play an important regula- tory role in the normal hematogenesis and immune system, There are two common gene mutation of FLT3, which are called internal tandem duplication and point mutation. It has overexpression in acute myelogenous Leukemia（AML） ,FLT3-1TD is the most common gene mutation in AML. FLT3 expression can be used as a gene symbol in the diagnosis of leukemia and the detection of minimal residual disease. This article reviews the relativity of FLT3 mutation with the genesis, development and prognosis of different kinds of leukemia.
作者 李国嫱（综述） 王晓敏（审校）
机构地区 新疆医科大学 新疆维吾尔自治区人民医院血液科
出处 《医学综述》 2009年第8期1147-1149,共3页 Medical Recapitulate
关键词 FLT3 基因 突变 FLT3-ITD 白血病 FLT3 Gene Mutation FLT3-ITD Leukemia
分类号 R733.7 [医药卫生—肿瘤]
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参考文献22

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二级参考文献15

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医学综述
2009年 第8期

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