摘要
目的 研究解郁胶囊对小鼠的急性毒性反应。方法 通过预实验,未找到动物的半数致死量后,采用24h内最大浓度3次灌胃给药,观察给药后2周内小鼠体质量、行为及死亡等情况。结果 给药组小鼠观察期内无明显因药物引起的中毒反应及死亡情况。小鼠的一日最大给药剂量为81.84g生药/kg体质量,相当于临床成人(70kg)每日常量(0.40g生药/kg)的204倍。结论 解都胶囊无明显急性毒性反应。
Objectlve To study Jieyu capsule on acute toxicity in mice. Methods Through the pre-experiment, did not find the half lethal dose animals after 24h using the largest concentration of orally administered 3 times to observe the 2 weeks after administration of mouse body weight, behavior and death and so on. Results Drug-treated mice had no significant observation period due to drug-induced toxic reactions and death. Day in mice for the largest dose 81.84g pharmacognostic/kg body mass,which is equivalent to the clinical adult (70 kg)daily constants(0. 40 g crude drug/kg)204 times. Conclusion Jie yu capsules no obvious acute toxicity.
出处
《医学综述》
2009年第8期1255-1257,共3页
Medical Recapitulate
基金
甘肃省自然科学基金(3ZS061-A25-113)
关键词
解郁胶囊
急性毒性
试验研究
最大给药量
半数致死量
Jie yu Capsule
Acute toxicity
Experimental study
Maximum dosage
Medial lethal dose