曲马多联合氟比洛芬酯预防全麻苏醒期躁动

Tramadol with Flurbiprofen Axetil Reduces Recovery Restlessness after General Anesthesia

目的探讨术中应用曲马多联合氟比洛芬酯预防全麻苏醒期躁动的效果。方法选择ASAⅠ～Ⅱ级全身麻醉下进行腰椎髓核摘除患者90例,随机分为3组,各30例。Ⅰ组给予曲马多0.8mg·kg-1;Ⅱ组给予曲马多1.6mg·kg-1;Ⅲ组给予氟比洛芬酯0.8mg·kg-1,曲马多0.8mg·kg-1,在手术结束前20min静脉给药,观察比较苏醒期三组患者的躁动发生情况、疼痛评分及不良反应(恶心、呕吐等)。结果Ⅱ组和Ⅲ组患者躁动发生率和疼痛评分均低于Ⅰ组(P<0.05),Ⅱ组和Ⅲ组间差异无显著性(P>0.05)。Ⅲ组不良反应发生率小于Ⅰ组和Ⅱ组(P<0.05)。结论术中应用曲马多联合氟比洛芬酯对预防全麻苏醒期躁动具有良好的效果,并能降低不良反应发生率。

Objective To observe the effect of flurbiprofen axetil and tramadol on treating the recovery restlessness after general anesthesia. Methods Ninety patients were recruited into the study and divided into three groups： group I received tramadol 0.8 mg · kg ^-1, group Ⅱ received tramadol 1.6 mg· kg ^-1 , group Ⅲ received flurbipmfen axetil 0.8 mg· kg ^-1 and tramadol 0.8 mg· kg ^-1. All the patients were intravenous administered twenty minutes before the end of surgery. The level of restlessness, pain scores and incidence of side effect were recorded. Results The level of restlessness and pain scores were significantly lower in group Ⅱ and group Ⅲ compared to those in group Ⅰ （P 〈 0. 05）. No significant difference between group Ⅱ and group Ⅲ （P 〉 0. 05） was found. The incidence of nausea and vomiting in group Ⅱ was higher than that in the others. Conclusion Flurbiprofen axetil with tramadol can degrade the level of recovery restlessness after general anesthesia with less side reactions.