N-(2,6-二甲苯基)-2-(1-哌嗪基)乙酰胺纯化工艺研究

Study on the Purification Process of N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

N-(2,6-二甲苯基)-2-(1-哌嗪基)乙酰胺合成过程中,会同时有产品及哌嗪双取代副产物生成,通过研究两者在常规溶剂中的溶解度,利用溶解度差异,选用乙醇对产品进行纯化,革除了原有不适于工业化规模生产的乙醚重结晶纯化工艺。

The disubstitution byproduct would be synthesized at the same time during the synthesis process of N-（2,6-dimethylphenyl）-2-（piperazin-l-yl） acetamide. The paper pays more attention to the study of the solubility between them in different common solvents. Successfully get rid of the process of using ether to recrystallize with purifying the product by using ethanol instead.