摘要
目的:探讨胃肠道间质瘤的临床病理特征、免疫组化特点、生物学行为以及诊治情况。方法:采用免疫组化S-P法检测29例胃肠道间质瘤CD117,CD34,SMA、Desmin、NSE、S-100等蛋白的表达情况,并进行临床病理分析。结果:29例胃肠道间质瘤CD117阳性表达26例占89.7%,CD34阳性表达21例,占72.4%。随访18例病人,有8例复发或死亡,其中NSE和(或)S-100蛋白阳性表达6例。在潜在恶性和恶性患者CD117、CD34、SMA、NSE、S-100等蛋白的表达与良性患者有明显差异,但Desmin的表达两者没有差异。结论:胃肠道间质瘤CD117及CD34是较特异的标记物。NSE、S-100蛋白阳性表达者在判定恶性时需高度重视,应行根治性切除。
Objective: To investigate the clinicalpathological characteristics and prognosis and treatment of gastrointestinal stromal tumors. Methods: 29 cases were detected by immunohistochemical method and diagnosed as GISTs. Their pathological features,immunohistochemical phenotypes, clinical manifestations were analyzed. Results: 26 cases were positive for CDl17 (89.7%) ,21 cases were positive.for CD34(72. 4%). 8 cases recurred and died, including 6 cases were positive for NSE or 8-100. Conclusions: The diagnosis of GIST depends on pathological observation and immunohistochemical study. CD117 is a sensitive marker for the diagnosis of GIST. Surgical resection is the choice for treating GIST, especially the case with positive for NSE or S-100.
出处
《数理医药学杂志》
2009年第2期167-169,共3页
Journal of Mathematical Medicine
关键词
胃肠道间质瘤
临床病理
免疫组织化学
治疗
gastrointestinal stromal tumors(GIST)
pathology
clinical
immunohistochemistry