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重组腺相关病毒载体在肺癌治疗中的应用 被引量:1

Progress of recombination Adeno-associated virus vectors for lung cancer gene therapy
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摘要 重组腺相关病毒(recombination Adeno-associated virus,rAAV)突出的特点使其成为基因治疗载体中的佼佼者,本文综述了rAAV基因药物在肺癌治疗中取得的进展并对其未来发展趋势进行了探讨。 Recombinant adeno-associated virus(rAAV) vectors expressing therapeutic gene products have shown great promise for human gene therapy. This review summarizes recent developments of rAAV in lung cancer therapy, and evaluates the challenges for translation of promising research of rA_AV gene medicine to clinical applications.
出处 《海峡药学》 2009年第3期8-11,共4页 Strait Pharmaceutical Journal
基金 国家"863计划"2007AA02Z194资助
关键词 重组腺相关病毒载体 肺癌 治疗 Recombinant adeno-associated virus vector Lung cancer Therapy
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  • 1PAN Qiuwei,CAI Rong,LIU Xinyuan,QIANCheng.A novel strategy for cancer gene therapy:RNAi[J].Chinese Science Bulletin,2006,51(10):1145-1151. 被引量:4
  • 2Pike SE, Yao L, Jones KD, et al. Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth. J Exp Med, 1998, 188(12): 2349-2356.
  • 3Pike SE, Yao L, Setsuda J, et al. Calreticulin and calreticulin fragments are endothelial cell inhibitors that suppress tumor growth. Blood, 1999, 94(7): 2461-2468.
  • 4I Xiao F, Wei Y, Yang L, et al. A gene therapy for cancer based on the angiogenesis inhibitor, vasostatin. Gene Ther, 2002, 9(18): 1207-1213.
  • 5Li L, Yuan YZ, Lu J, et al. Treatment of pancreatic carcinoma by adenoviral mediated gene transfer of vasostatin in mice. Gut, 2006, 55(2): 259-265.
  • 6Liu MH, Imam H, Oberg K, et al. Gene transfer of Vasostatin, a calreticulin fragment, into neuroendocrine tumor cells results in enhanced malignant behavior. Neuroendocrinology, 2005, 82(1): 1-10.
  • 7Okada F, Rakj J, Croix BT, et al. Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factoryvascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells. Proc Natl Acad Sci USA, 1998, 95(7): 3609-3614.
  • 8[1]Dai Y, Roman M, Naviaux RK, et al. Gene therapy via primary myoblasts :long term expression of factor Ⅸ protein following transplantation in vivo[J]. Proc Natl Acad Sci USA,1992, 89: 10892-10895.
  • 9[2]Naldini L, Blome V, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector[J]. Science, 1996, 272: 263-267.
  • 10[3]Blaese RM ,Culver KW, Miller AD, et al. T-lymphocyte-directed gene therapy for ADA-SCID: initial trial results after 4 years[J]. Science, 1995,270:475-480.

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