内分泌治疗后前列腺癌患者肿瘤组织干/祖细胞数量的变化

The change of the number of stem /progenitor cells in human prostate cancer tissue after endocrine therapy

目的探讨内分泌治疗后前列腺癌患者肿瘤组织干/祖细胞数量的变化。方法收集山西医科大学第一医院2006年1月至2010年12月收治的18例经过内分泌治疗前后的前列腺癌患者肿瘤组织标本,采用免疫组织化学SABC法检测干/祖细胞标志物CD133的表达。结果经过内分泌治疗后,前列腺癌患者肿瘤组织中CD133阳性的细胞数量由(1.037±0.523)%增加到(8.148±1.779)%,差异具有统计学意义(P<0.001)。结论内分泌治疗可以导致前列腺癌干/祖细胞数量的增加,这可能是现有内分泌治疗最终失败的原因之一。

Objective To detect the change of the number of stem/progenitor cells in human prostate cancer tissue after endocrine therapy.Methods 18 pairs of human prostate cancer tissue before and after endocrine therapy were collected in First Hospital of Shanxi Medical University from Jan 2006 to Dec 2010.Immunohistochemistry SABC was used to detect the expression of stem cell marker CD133 in the cancer cells.Results After endocrine therapy,the number of CD133 positive cells increased,from(1.037 ± 0.523) % to(8.148 ± 1.779) %.The difference had significance(P < 0.001).Conclusions Endocrine therapy can increase the number of prostate cancer stem /progenitor cells,which could be one of the reasons of failure of existing endocrine therapy.