乳腺黏液癌与普通型乳腺浸润性导管癌临床病理特征和ER、PR、P53、C-erbB-2、Ki-67表达差异分析

The clinicopathological characteristics and expression of ER,PR,C-erbB-2,P53,Ki-67 between breast mucinous carcinoma and invasive ductal carcinoma-not otherwise specified

目的探讨乳腺黏液癌(MC)和普通型浸润性导管癌(IDC-NOS)的临床病理特征及ER、PR、C-erbB-2、P53、Ki-67表达的差异,认识乳腺黏液癌低度恶性的生物学行为。方法收集2009年1月至2011年12月我院收治并经病理科常规免疫组化检测ER、PR、C-erbB-2、P53、Ki-67的MC病例20例和IDC-NOS病例60例。分析不同组患者的年龄、肿物大小、淋巴结转移情况、临床分期以及免疫组化指标表达情况。结果 (1)MC在肿块大小、淋巴结转移以及临床分期方面均明显不同于IDC-NOS,前者肿块较小,淋巴结转移率低,临床分期多为早期;(2)MC中ER、PR表达率显著高于IDC-NOS,C-erbB-2、P53和Ki-67阳性率显著低于IDC-NOS。结论 MC是一种低度恶性、低侵袭性的肿瘤,其激素水平较高,增殖活性较低。

Objective To explore the differences of the clinicopathological characteristics and expression of ER,PR,C-erbB-2,P53,Ki-67 between breast mucinous carcinoma(MC)and invasive ductal carcinoma-not otherwise specified(IDC-NOS).Methods The data of 20 cases of MC and 60 cases of IDC-NOS from Jan 2009 to Dec 2011 were collected,and immunohistochemical detections of ER,PR,C-erbB-2,P53 and Ki-67 were performed.The ages of patients,tumor sizes,metastasis of lymphnode and TNM staging were analyzed.Results (1)The tumor sizes,metastasis of lymphnode and TNM staging of MC were different from those of IDC-NOS.The MC showed smaller volumes,lower incidence of lymphnode metastasis and earlier TNM staging.(2)The positive rate of ER and PR were higher in MC,and those of C-erbB-2,P53 and Ki-67 were lower in MC.Conclusions MC have more favorable pathological characteristics than IDC-NOS with lower hormone levels and higher proliferative activity.