心境障碍患者自杀行为与非配负波的相关性研究

Study of the relationship between suicide and changes of mismatch negativity in patients with depression

目的探讨心境障碍患者的非配负波(MMN)变化与自杀行为的关系。方法记录并比较57例伴或不伴自杀行为的心境障碍患者及40名正常对照者的MMN。结果正常对照者的MMN主成分波幅为(8.5±1.5)μV,有或无自杀史的心境障碍者分别为(3.4±1.5)μV和(5.3±2.5)μV,两者差异有显著统计学意义。正常对照者的MMN潜伏期为(185.7±20.6)ms,有或无自杀史的心境障碍者分别为(209.8±25.6)ms和(199.1±22.6)ms,两者差异亦有显著统计学意义。结论 MMN波幅下降和潜伏期延长与患者的自杀史相关。MMN具有对伴有自杀行为的心境障碍患者进行监测的临床应用价值。

Objective To explore the relationship between suicide and changes of mismatch negativity(MMN) in patients with depression.Methods The MMN were recorded and compared between 40 normal controls and 57 depressed patients with or without suicide.Results The amplitudes of major components of MMN in normal controls were(8.50±1.51)μV which was significantly higher than that in depressed patients with suicide(3.39±1.51)μV or without suicide(5.31±2.45)μV.The latencies of MMN in normal controls were(185.7±20.6) ms which was also significantly shorter than that in depressed patients with suicide(209.8±25.6) ms or without suicide(199.1±22.6)ms.Conclusion Decreased amplitude and prolonged latency of the MMN were related to the history of suicide within depressed patients.The clinical usefulness of MMN was to monitor the depressed patients with suicide.