阿司匹林联合氯吡格雷治疗急性进展性脑梗死的临床观察

Clinical observation of treatment of acute progressive cerebral infarction by combination of aspirin with clopidogrel

目的观察经阿司匹林治疗后病情仍加重的急性进展性脑梗死(APCI)患者,联合使用氯吡格雷治疗的临床疗效及安全性。方法 76例APCI患者分为治疗组和对照组。治疗组用阿司匹林联合氯吡格雷治疗,对照组单用阿司匹林治疗。在治疗前后对2组患者进行斯堪的那维亚(SSS)评分。结果治疗组的病情进展持续时间较对照组短;治疗组的SSS评分较对照组高。结论阿司匹林联合氯吡格雷可延缓APCI的进展。

Objective To observation the clinical efficacy and safety of treatment in patients with acute progressive cerebral infarction(APCI) after aspirin therapy by combination of aspirin with clopidogrel. MethodsSeventy-six patients with APCI were divided into two groups,the treatment group and the control group.The treatment group was given aspirin combined with clopidogrel while the control group was given aspirin only.The Scandinavian Stroke Scale(SSS) scores were assessed in the two groups before and after treatment. ResultsCompared with the control group,the treatment group had shorter mean duration of progression and higher SSS score. Conclusion Combination of aspirin and clopidogrel may delay the progression of APCI.