老年冠心病与骨质疏松的相关性研究

目的探讨老年冠心病与骨质疏松的相互关系,并为临床冠心病的防治工作开拓新的思路。方法随机选取117例心内科拟诊为冠心病的患者,根据冠状动脉造影检查结果,分为冠心病组及非冠心病组;根据骨密度检查结果分为骨质疏松组与非骨质疏松组,比较男性及女性骨质疏松组与非骨质疏松组之间的冠心病发病率的差异,进一步比较两组间的冠脉粥样硬化情况,分析骨密度各个测定部位在冠心病预测中的意义及骨质疏松在冠心病发病中所占的比重。结果 (1)女性骨质疏松组与非骨质疏松组相比,前者的冠心病发病率高于后者(P<0.05)。(2)男性骨质疏松组与非骨质疏松组相比,两组间的冠心病发病率差异无统计学意义(P>0.05)。(3)女性骨质疏松组与非骨质疏松组间冠脉的Gensini分级数相比,差异有统计学意义(P<0.05)。(4)分别通过比较女性0支、1支、2支病变情况间及Gensini分级中轻、重度病变间的各个部位骨密度值,发现股骨近端的骨密度值差异有统计学意义(P<0.05,P<0.01)。(5)通过将骨质疏松与冠心病传统危险因素相比较,发现年龄、高血压、高血脂、骨质疏松的相对危险度分别为1.243、1.799、4.107、5.181。结论男性患者冠心病与骨质疏松无明显相关性;在女性骨质疏松组的冠心病发病率高于非骨质疏松组,骨质疏松在冠心病的发病中占重要的地位。

Objective To probe the relation between coronary artery disease and osteoporosis by comparingt he morbility of coronary artery disease and the degree of coronary atherosclerosis between osteoporosis group and non-osteoporosis group in female and male,and to expand new path for preventing coronary artery disease.Methods 117 hospital patients in Cardiology Department were included in the study,They were divided intocoronary artery disease group and non-coronary artery disease group by coronary angiography.All of them wered etemined liver and kidney biochemistry,fasting plasma lipid and blood sugar,and bone mineral density in thec orresponding time period.They were divided into osteoporosis group and non-osteoporosis by measuring bonem ineral density,and then we analyzed respectively the difference of coronary artery disease morbility and the degree of coronary atherosclerosis between the two groups in female and male in the condition that there was not statistical difference between osteoporosis group and non-osteoporosis group on basic datas.By these results,we probed the relation between the severity degree of coronary artery disease and osteoporosis,the significance of bone density in various detemination positions to predict coronary artery disease and the comparision between osteoporosis and traditional risk factors of coronary artery disease.Results(1)There was statistical difference between osteoporosis group and non-osteoporosis group in female on the morbility of coronary artery disease(P<0.05).(2)There was not statistical difference between osteoporosis group and non-osteoporosis group in male ont he morbility of coronary artery disease(P>0.05).(3)There was statistical differenc on the Gensini class of coronary artery disease between osteoporosis group and non-osteoporosis group in female(P<0.05).(4)By comparing bone mineral density of each position in different vasculopathy(the branch and the Gensini class),we foundt hat femoral bone mineral density was most important(P<0.05,P<0.01).(5)By comparing osteoporosis and tradional risk factors of coronary artery disease,we found that the odd rate of age,hypertension,hyperlipemia,osteoporosis were respectively 1.243、1.799、4.107、5.181.Conclusions The relation between osteoporosis and coronary artery disease in male didn't exist,b ut it existed in female.There was statisticald ifference on the severity of coronary atherosclerosis between osteoporosis group and non-osteoporosis group in female.osteoporosis had an important rank int he morbility of coronary artery disease,even exceeded traditional risk factors.