凯妮汀配合干扰素治疗复发性念珠菌性阴道炎临床疗效观察

The clinic outcomes of recurrent vulvovaginal candidiasis treated with gynocanesten added pegasys

目的:探讨凯妮汀配合干扰素a-2a治疗复发性念珠菌性阴道炎的临床疗效。方法:对我院妇科门诊确诊为复发性念珠菌性阴道炎124例患者随机分为观察组69例和对照组55例,观察组采用凯妮汀(500mg/片)1片,于擦洗阴道内分泌物后置阴道后穹窿处。1周后重复使用1枚。配合干扰素200万单位/天肌注,隔天一次,3次/周,连用2周。对照组将制霉菌素栓1枚(每枚含制霉菌素20万单位)置入阴道内,每日1次连续6日为一疗程,连用2周。配合干扰素,用法同上。且分别在2、4、8周末复查。结果:观察组的疗效显著高于对照组。在2、4、8周末,分别是60(86.95%)与30(54.54%),64(92.75%)与36(65.45%),68(98.55%)与38(69.09%)(P<0.01)。两组复发率比较,观察组明显低于对照组在2、4、8周末,分别是2(2.90%)与4(7.27%),4(5.80%)与8(14.54%),6(8.69%)与12(21.81%),(P<0.01)。结论:凯妮汀配合干扰素治疗复发性念珠菌性阴道炎安全、有效。

[Objective]To evaluate the clinic outcomes of Recurrent vulvovaginal candidiasis treated with gynocanesten added Pegasys.[Method]124 recurrent vulvovaginal candidiasis victims are divided into 2 groups,the control group(55) were treated with Nysfungin Vaginal Suppositories,200000×1 pro vaginal,qd×6,the treatment group(69) were treated with gynocanesten 500mg pro vaginal st repeated after one week.Pegasys was used in2 groups,2000000 im qod,tiw×14d.All cases were called back to check respectively on the second,fourth,and eighth weekends.[Result]Recovery rate in the treatment group had significant increase than that of the control group,on the second,fourth,and eighth weekends,60(86.95%)vs 30(54.54%),64 (92.75%)vs 36(65.45%),68(98.55%)vs 38(69.09%),P<0.01).Relapse rate in treatment group were lower man that of the control group on the second,fourth,eighth weekend,2(2.90%)vs 4(7.27%),4(5.80%)vs 8(14.54%),6(8.69%) vs 12(21.81%),P < 0.01 ).[Conclusion]gynocanesten added toPegasys is more effective than Nysfungin Vaginal Suppositories in treating Recurrent vulvovaginal candidiasis.