乙型肝炎前S1蛋白诊断价值分析

The Significance of HBV Pre-S1 Protein in Diagnosis of Hepatitis B

目的探讨山东邹城地区420例乙型肝炎患者前S1检测水平及其对乙型病毒性肝炎的诊断意义。方法用ELISA法检测HBsAg阳性患者的前S1水平,同时检测HBV两对半和血清HBV-DNA,并进行对比分析。结果前S1抗原阳性检测率低于HBsAg阳性检测率,略高于HBeAg阳性检测率,与HBV-DNA阳性率基本持平。前S1抗原与HBeAg、HBV-DNA的符合率均达到80%以上。前S1抗原与HBeAg、HBV-DNA具有显著性差异(P<0.05)。结论前S1蛋白对HBV病毒体内复制水平、估计预后具有重要的参考价值。

Objective To study the clinical significance of HBV Pre-S1 protein assay in diagnosis of hepatits B.Methods The serum Pre-S1 Ag,HBV classic marks and HBV-DNA were detected in 420 patients with positive HBsAg in Yanzhou of Shandong province.The positive rates and the relationship between them were analyzed.Results Among 420 experimental individuals,the positive rates of PreS1 in 420 were lower than that of HBsAg and slightly higher than that of HBeAg and similar to that of HBV-DNA.All the positive rates of PreS1,HBeAg and HBV-DNA were more than 80%.The difference between them was significant(P<0.01%).Conclusions PreS1 could be used as a sensitive,simple marker for early diagnosis of hepatits B,and it plays a very important role in the evaluation of HBV DNA replication and prognosis.