2087株革兰氏阴性杆菌的来源分布及耐药性分析

Analysis of resistance of 2087 gramnegative bacilli from various sources to antibiotics

分析我院2006.1～2007.3临床分离的2087株革兰氏阴性杆菌的来源组成及主要革兰氏阴性杆菌的耐药状况.用VITEK AMS32鉴定细菌,排除同一患者的重复菌株,按统一方案用Kirby-Bauer法进行药敏试验,按美国国家临床实验室标准委员会2005年标准判读结果.结果 分离率居前五位的革兰氏阴性杆菌是铜绿假单胞菌、大肠埃希氏菌、肺炎克雷伯氏菌、鲍氏不动杆菌和阴沟肠杆菌.对革兰氏阴性杆菌耐药率平均最低的抗生素依次是亚胺培南(16%)、头孢他啶(26%)、头孢吡肟(26%);耐药率最高的抗生素是氨苄青霉素(92%)、复方新诺明(73%).结论 铜绿假单胞菌是临床标本中最常见的革兰氏阴性杆菌,亚胺培南、头孢他啶和头孢吡肟对革兰氏阴性杆菌的耐药率最低.

Objective To investigate the antibiotics resistant rate and distribution from various sources of 2087 strains of gram negative bacilli.Vetek AMS 32 was used to identify bacteria and perform the drug susceptibility tests. Bacilli in front position of isolating rate were Escherichia coli,Klebsiella pneumoniae,Pseudomonas aeriginosa,Acinectober calcoaceti,Enterobacter cloacae.The minimum antibiotic resistant rate were imipenem(16%),ceftazidine(26%),Cefepime(26%).The maximum antibiotic resistant rate were ampicillin(92%), Trimethoprim/Sulfamethoxazole(78%).Pseudomonas aeruginosa is the most common gram negative bacilli in clinical samples.Imipenem,ceftazidine and Cefepime have minimum antibiotic resistant against gram negative bacilli.