恶性肿瘤患者梅毒血清反应素试验生物学假阳性分析

Analysis of Biologic False-positive Reactions in Treponema Pallidum serum reagin test of the patients with Malignant Tumors

目的了解恶性肿瘤患者梅毒TP(Treponema Pallidum)血清反应素试验假阳性率并进行临床分析。方法采用梅毒甲苯胺红不加热血清试验(TRUST)对2671例恶性肿瘤患者进行初筛,TRUST阳性(+)者用梅毒螺旋体明胶颗粒凝集试验(TPPA)进行确证。结果2671例恶性肿瘤患者中39例(1.46%)TRUST阳性,经TPPA确证后,仍有3例(0.11%)阳性;男女患者间TRUST假阳性率差异均无统计学意义(P>0.05),男女患者间肿瘤构成比则有显著性差异(P<0.01),男性以肺癌最多,其次是直肠癌;女性则以子宫内膜癌最多,其次是乳腺癌。同时,不同恶性肿瘤的TRUST假阳性率差异亦有显著性意义(P<0.01),以子宫内膜癌最高,其次是胰腺癌、卵巢癌等。结论恶性肿瘤患者TRUST假阳性发生率接近2%且无明显性别差异,假阳性患者的肿瘤构成比存在显著性别差异,不同恶性肿瘤的TRUST假阳性率差异亦有显著性。

Objective To investigate the rate of False-positive Reactions of Treponema Pallidum serum reagin test of the patients with Malignant Tumors and to analyze their clinical features.Methods TRUST was used to find the positive samples,then TPPA was used to confirm.Results 39 patients had TRUST biologic false-positive reactions,3 patients still had TPPA positive reaction.No significant differences were found in the rate of false-positive reactions of TRUST between male and female patients(P>0.05).However,there were significant differences in tumor constituent ratio between male and female patients(P<0.01).Lungcancers were the most frequent and then rectalcancers in males,while carcinomas of endometrium were the most frequent and then brest cancers in females.Moreover,the rates of false-positive reactions of TRUST varied with different cancers(P<0.01).Carcinomas of endometrium were the most frequent in the patients with false-positive reactions of TRUST,then pancreatic-cancers,ovarycancers and etc.Conclusions Nearly 2% patients with cancers have TRUST biologic false-positive reactions and no significant gender differences exist.There are significant gender differences in tumor constituent ratio,and there are also significant differences in the rates of biologic false-positive reactions of TRUST among different cancer.