紫杉醇联合5-氟尿嘧啶、亚叶酸钙方案治疗晚期胃癌近期疗效评价

Clinical study on taxol plus 5-fluorouracil/leucovorin combination chemotherapy for patients with advanced gastric cancer

目的评价含紫杉醇(TAX)联合5-氟尿嘧啶(5-Fu)、亚叶酸钙(LV)组成的TF方案治疗晚期胃癌的临床疗效及安全性。方法55例病理证实的晚期胃癌患者接受TF方案治疗,21 d为1周期,连用2～3个周期后评价疗效。结果55例患者均可评价疗效及毒副作用,有效率为45.45%。临床受益反应(CBR)35例可评价,疼痛缓解率为86.6%,Karnofsky评分增加≥20分者占56.4%。白细胞数减少发生率为56.4%,Ⅲ度以上占10.9%。胃肠道反应发生率为43.6%。结论TF方案治疗晚期胃癌疗效确切,CBR高,不良反应可以耐受,对多次使用含5-Fu及衍生物方案治疗过的患者仍有一定疗效。

Objective The current study was designed to evaluate the efficacy and toxicity of taxol plus fluorouracil(TF)chemotherapy in patients with advanced gastric cancer.Methods 55 patients with ad- vanced gastric cancer were treated with TF schedule.A treatment cycle lasted 21 days.The efficacy was eval- uated after 2～3 cycles of the chemotherapy.Results These 55 patients were evaluated the efficacy and the toxicity.The total efficiency rate of TF schedule was 45.45 %.Clinical Benefit Response(CBR)were evaluated in 35 patients.Ache remission rate was 86.6 %.The main side effect of toxicity was neutropenia.The total re- sponse neutropenia is 56.4 %.The aboveⅢstage was 10.9 %.The rate of nausea and vomiting was 43.6 %. Conclusion The combination of taxol and fluorouracil is a high response protocol with mild toxicity.TF schedule has high efficiency for advanced gastric cancer,especially for the patients who had had chemothera- py with fluorouracil.