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生长分化因子15与大肠癌关系的研究进展

Advance on growth differentiation factor 15 and its relation with colorectal cancer
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摘要 生长分化因子-15(GDF-15)是转化生长因子超家族(TGF-βs)的一个远支成员,它在多种损伤及肿瘤等病理、生理过程中发挥促凋亡、抗肿瘤、神经营养以及心肌保护等作用。文章主要综述GDF-15基因、GDF-15及其抗体的结构与功能特点,大肠癌(CRC)患者血清中GDF-15含量、基因型与发病的关系,多种抗肿瘤物质对GDF-15在大肠癌组织及细胞中表达的影响。 GDF-15,a distant member of the TGF-superfamily,is identified as an apoptotic accelerat- ing,anti-tumorigenesis and nerve2nutritional factor in varied injures and tumors and has cardioprotective ac- tivity.The characteristics and roles of GDF-15 gene/protein and antibodies are expounded besides the rela- tionship between GDF-15 serum level/genetypes and CRC.It is also discussed here that some antitumorigenic substances inducing GDF-15 in CRC tissues and CRC cells.
作者 王冠华 程牛亮
机构地区 山西医科大学生物化学与分子生物学教研室
出处 《肿瘤研究与临床》 CAS 2007年第4期283-285,共3页 Cancer Research and Clinic
关键词 肠肿瘤 基因型 CRC Genetype
分类号 R735.34 [医药卫生—肿瘤]
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参考文献10

  • 1Strelan J,Bottner M,,Lingor P,et al.GDF-15/MIC-1,a novel member of the TGF-beta superfamily[].Journal of Neural Transmission.2000
  • 2Bootcov MR,Bauskin AR,Valenzuela SM,et al.MIC-1,a novel macrophage inhibitory eytokine,is a divergent member of the TGF-βsuperfamily[].Proceedings of the National Academy of Sciences of the United States of America.1997
  • 3Hromas R,Hufford M,Sutton J,et al.PLAB,a novel placental bone morphogenetic protein[].Biochimica et Biophysica Acta.1997
  • 4Seung JB,Jonathan M,Thomas E.Molecular cloningand charac- terization of human nonsteroidal anti-inflammatory drug-activated gene promoter[].Biological Chemistry.2001
  • 5Liu T,Bauskin APt,Zaunders J,et al.Macrophage inhibitory cy- tokine 1 reduces cell adhesion and induces apoptosis in prostate cancer ceils[].Cancer Research.2003
  • 6Fairlie WD,Russell PK,Wu WM,et al.Epitope mapping of the transforming growth factor-βsupeffamily protein,macrophage in- hibitory cytokine-1(MIC-1):identification of at least five distinct epitope specificities[].Biochemistry.2001
  • 7Cheung PK,Woolcock B,Adomat H,et al.Protein profiling of mi- crodissected prostate tissue links growth differentiation factor 15 to prostate carcinogenesis[].Cancer Research.2004
  • 8Bauskin AR,,Zhang HP,Fairlie WD et al.The propeptide of maerophage inhibitory cytokine(MIC-1),a TGF-beta supeffamily member,acts as a quality control determinant for correctly folded MIC-1[].EMBO Journal.2000
  • 9Xu J,Kimball TR,Lorenz JN,et al.GDF15/MIC-1 functions as a protective and antihypertrophie factor released from the myocardi- um in association with SMAD protein activation[].Cite Res.2006
  • 10Back SJ,Kim JS,Jackson FR,et al.Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition andapep- tosis in coloncancer cells[].Carcinogenesis.2004
肿瘤研究与临床
2007年 第4期

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