肿瘤患者CD_(62p)和CD_(63)测定及其临床意义

Detection and clinical analysis of CD_(62p)and CD_(63)in cancer patients

目的比较不同疾病状态下活化血小板测定值的差别及使用阿司匹林防治血栓的效果。方法采用流式细胞仪测定126例肿瘤患者和60例非肿瘤患者外周血活化血小板 CD_(62p)和 CD_(63)的表达以及服用阿司匹林后的变化。结果肿瘤患者外周血的活化血小板 CD_(62p)和 CD_(63)的表达量明显高于非肿瘤患者(P<0.05),有血栓形成的肿瘤患者外周血的活化血小板 CD_(62p)和 CD_(63)的表达量明显高于无血栓形成的肿瘤患者(P<0.05),有血栓的肿瘤患者的活化血小板经过阿司匹林干预治疗后明显下降(P<0.05)。结论测定活化血小板可以预测肿瘤患者存在高凝状态风险性的大小。同时,服用小剂量肠溶阿司匹林可以降低外周血活化血小板 CD_(62p)和 CD_(63)。

Objective To compare the measured values of activated platelets in different disease sta- tus,and the prevention and treatment effects of aspirin for thromboembolism.Methods Flow cytometry was used to detect CD_(62p)and CD_(63)level in peripheral activated platelets(PAP) of 126 cases of tumor patients and 60 cases of non-tumor patients, and detect the changes after taking aspirin. Results The CD_(62p)and CD_(63) levels of PAP were evidently higher in tumor patients than that of non-tumor patients(P<0.05).In those with the formation of thromboembolism, CD_(62p)and CD_(63)of PAP were evidently higher than those without formation of thromboembolism(P<0.05).After using aspirin interfering therapy,the thromboembolism decreased evident- ly(P<0.05).Conclusion The detection of PAP can prediet the risk of high coagulation status of tumor pa- tients.At the same time,the use of low dose aspirin can decrease the CD_(62p)and CD_(63)value of PAP.