草酸铂联合卡培他滨治疗晚期大肠癌临床观察

The clinical observation of oxaliplatin combined with capecitabin for patients with advanced colorectal cancer

目的观察草酸铂(Oxaliplatin)联合卡培他滨(商品名:希罗达)治疗晚期大肠癌的近期疗效及患者不良反应。方法采用草酸铂130mg/m^2,静脉滴注2 h,第1天,希罗达2000mg·m^(-2)·d^(-1),分2次口服,第1天至第14天,联合治疗晚期大肠癌患者42例,21 d为1个周期,至少连用3个周期。结果全组中完全缓解2例、部分缓解15例,有效率40.5%(17/42)。治疗后Karnofsky评分提高24例(57.1%)。患者主要不良反应为脱发、外周感觉神经异常、消化道反应、骨髓抑制,均可以耐受。结论草酸铂联合卡培他滨方案治疗晚期大肠癌具有较好的疗效,患者不良反应可以耐受,值得深入研究。

Objective To observe the therapeutic effect and toxicity reaction of Oxaliplatin com- bined with XeLoda in the treatment of 42 patients with advanced colorectal cancer.Methods All the pa- tients were treated with Oxaliplatin(130 mg/m^2,ivgtt for 2 h,d1)combined with XeLoda(2000 mg·m^(-2)·d^(-1), po,bid,d1 to d14).The regime was repeated every 21 days for at least 3 consecutive cycles.Results The to- tal response rate was 40.5%(17/42)in which 2 got CR and 15 PR.24 patients got Kamofsky score increased. The major toxic effects were alopecia,peripheral neuritis,gastrointestinal tract reactions and myelosuppression. Conclusion Oxaliplatin combined with XeLoda regimen is effective in the treatment of advanced colorectal cancer,and its toxicity is tolerable.It is worth studying in the future.