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E1B缺失腺病毒H101的研究进展 被引量：1

Review of the empirical study and clinical research of E1B-deleted virus
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摘要 E1B缺失腺病毒H101是采用基因重组技术对人5型腺病毒进行基因重组得到的一种溶瘤腺病毒,它主要是删除了人5型腺病毒的E1B-55×10~3和E3区19×10~3基因片段,具有在肿瘤细胞中特异性复制而最终导致溶瘤的特性。 H101 is a genetically modified Ad5 based,E1B-deleted and replication competent virus (oncolytic virus),in which the region of 2502 bp to 3327 bp was deleted and there was a C to T transition at position 2025 and it allow selective replication in and lysis tumor cells.
作者 叶玲 钱关祥 葛盛芳
机构地区 上海交通大学医学院生物化学与分子生物学研究室
出处 《肿瘤研究与临床》 CAS 2007年第6期429-432,共4页 Cancer Research and Clinic
基金 国家自然基金项目(30400536) 国家重大基础研究项目(No.2004CB518804)
关键词 腺病毒E1B蛋白质类 基因治疗 研究 E1B gene-deleted adenovirus Gene therapy Research
分类号 R730.5 [医药卫生—肿瘤]
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肿瘤研究与临床
2007年 第6期

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