雌激素受体、胰岛素样生长因子-1受体在不同大小子宫肌瘤中的表达

Expression and relation of ER,IGF-IR in the different size uterine leiomyoma

目的探讨雌激素受体(ER)、胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子-1受体(IGF-1R)与子宫肌瘤生长的关系。方法选取40例因子宫肌瘤行全子宫切除术的标本,取肌瘤组织和正常肌层组织制成石蜡切片,采用免疫组化SABC法测定ER、IGF-1、IGF-1R的蛋白表达。结果子宫肌瘤组织中ER、IGF-1R表达阳性率分别为67.5%及65.0%,高于宫壁组织的30.0%及20.0%(P<0.05),子宫肌瘤最大直径>5 cm组ER、IGF-1R阳性表达率均为30.0%,与≤5 cm组的80.0%及76.6%比较,差异有统计学意义(P<0.05)。结论ER、IGF-1R在子宫肌瘤发生、发展早期及中期起作用,而当子宫肌瘤生长到一定程度后,ER、IGF-1R对肿瘤的生长和增生调控能力逐渐缺失,ER与IGF-1R机制所起作用减弱,而促进子宫肌瘤进一步生长的原因可能与其他途径有关。

Objective To investigate the relationship between uterine leiomyoma and estrogen re- ceptor or insulin-like growth factor typeI or insulin-like growth factor typeⅠreceptor.Methods The ex- pressions of estrogen receptor,insulin-like growth factor typeⅠand insulin-like growth factor typeⅠreceptor were detected by immunohistoehemistry SABC.Results Expressions of ER and IGF-1R in uterine leiomy- oma were significantly higher than those in myomertrium(P<0.05).There were statistical significantly differ- ent between the group of diameter to be more than 5 cm and lower than 5 cm in the expressions of ER and IGF-1R of uterine leiomyoma.Conclusion ER and IGF-1R come into effect in the early and mid period of the uterine neoplasms' development.While the uterine neoplasms grow for a certain degree,the ability of the ER and IGF-1R that make the neoplasms grow,regulate and multiply gradualy disappears.The funtion of mechanism of ER and IGF-1R in weakened.However the reason to promote the Uterine neoplasms grow any longer possibly relates to other gateways.